cancer: New method for identifying most aggressive childhood cancers

A research group at Lund University in Sweden has found a new way to identify the most malignant tumours in children. The method involves studying genetic ‘micro-variation’, rather than the presence of individual mutations. In adult cancers[1], the tumour[2] cells are more genetically variable than healthy cells. When a cancerous cell divides, the chromosomes often end up in the wrong place, or break and combine in incorrect ways. However, it […]

lung: Changing diet to unmask cancer vulnerabilities and reduce cancer risk

Many recent studies showed that calorie restrictions reduce the incidence of cancer[1], whereas high-calorie diets cause obesity[2] and diabetes[3], both of which increase the risk of developing cancers. However, tumor[4] biology still hides complex mechanisms, as revealed by researchers from the Faculty of Medicine of the University of Geneva (UNIGE), Switzerland. In a study published in Cell Metabolism, scientists not only found the unexpected benefit that a change of diet […]

breast: Noisy data facilitates Dartmouth investigation of breast cancer gene expression

Researchers from Dartmouth’s Norris Cotton Cancer Center, led by Casey S. Greene, PhD, reported in Pacific Symposium on Biocomputing on the use of denoising autoencoders (DAs) to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties. “Cancers are very complex,” explained Greene. “Our goal is to measure which genes are being expressed, and to what extent they’re being expressed, and then […]

colorectal: SPECTAcolor viable next generation multinational cancer clinical trial infrastructure

SPECTAcolor’s successful start has demonstrated its viability to facilitate next generation cancer[1] clinical trials. It has been successfully implemented across 19 clinical centers located in nine countries in Europe, has now recruited over 500 patients since its launch in September 2013, and the observed frequency of mutations is similar to that observed in previous colorectal cancer[2] clinical trials. In addition, pathological review and core analyses of tumor[3] blocks shipped to […]

colorectal: Study examines NSAID use, risk of anastomotic failure following surgery

Use of nonsteroidal anti-inflammatory drugs (NSAIDs[1]) was associated with an increased risk of anastomotic leak at the surgical junction in patients undergoing nonelective colorectal procedures, according to a report published online by JAMA Surgery. NSAIDs are a broad class of drugs used to relieve pain and inflammation[2] and have long been used to treat postoperative pain. Their postoperative use has expanded with the recent development of intravenous formulations and because […]